GHRP-6 is a synthetic met-enkephalin analogue and growth hormone releasing peptide. GHRP-6 contains 6 amino acids including unnatural D-amino acids to facilitate growth hormone release (secretagogue). GHRP-6 administered experimental animals showed significant body weight, muscle growth, glucose metabolic rate, heart and brain functions, according to a study published in the Journal of Clinical Endocrinology and Metabolism. Instead of binding with GHRP-6 receptors, the biomolecule acts at ghrelin receptors. The effects of endogenous GH secretagogues differ from recombinant hGH. Endogenous growth hormones contain 5 isoforms; however, exogenous rHGH contains 20 kDal isoform only. Growth hormones release stimulating property of GHRP-6 reduces fat deposition and body mass. GHRP-6 exerts anti-inflammatory property and promotes liver health. Studies are underway to explore and understand the properties of GHRP-6. The molecular weight is 873.014 and molecular formula is C46H56N12O6.
The growth hormone releasing hormone is composed of both isomeric and natural forms of the amino acids in L and D configurations. The sequence is vital in signaling the body to secrete GH while blocking the activity of somatostatin an inhibitor that prevents optimal release of growth hormone. Research on the efficiency of the GHRP-6 and other blends are underway to ascertain their potency, half-life, and their synergistic approach. GHRP-6 acts on both the pituitary and hypothalamic sites; however, the primary target of the GHRP-6 is the hypothalamus. GHRP-6 activity is inhibited by somatostatin; however, an increased concentration of the hormone results in the increase of GH released per cell. The mechanism of stimulation of the GHRP-6 is not yet known. Moreover GHRP-6 has a positive feedback mechanism in accentuating the release of Ghrelin a hormone which induces hunger, gastric motility and gastric emptying.
GHRP-6 Chemical Profile
Molecular weight: 873.01
Peptide purity: > 99.0%
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